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وبینار بینالمللی در خصوص نوترون درمانی BNCT
فردا جمعه...
Join us on May 9th, 2024 at 11 UTC for a fascinating session on preclinical research in BNCT and the use of 3D models to replace animal testing in cancer studies.
Title: BNCT for Three-Dimensional Oral Cancer Model
👩⚕️ Speaker:
Dr. Kazuyo Igawa
Neutron Therapy Research Center, Okayama University
Brief abstract
There are growing expectations for novel radiation therapies to maintain and improve the quality of life of cancer patients as cancer function-preserving therapies. Boron neutron capture therapy (BNCT), one of the novel cancer radiation therapies, is covered by health insurance for head and neck cancer in Japan from 2020, and further development of boron agents and neutron sources and expansion of indications are underway.
However, BNCT requires preclinical studies on new boron agents and new accelerator-based BNCT systems to evaluate safety and efficacy, and thus requires a large amount of money and a long time to reach clinical application. On the other hand, the U.S. Food and Drug Administration (FDA) has declared that it will no longer be necessary to conduct animal testing in order to obtain approval for new drugs in 2022 and the Environmental Protection Agency (EPA) has issued a directive calling for a 30% reduction in requests for and funding of animal testing using mammals by 2025, and for the complete abolition of such testing by 2035. Therefore, there is a strong need for an alternative animal study model in BNCT.
The FDA uses alternative methods to reduce or replace animal testing in the evaluation of regulated products.
These methods include in vitro methods, in silico models, 3 D tissue culture, Stem cell research, Non-invasive diagnostic imaging, bioprinting and so on. In particular, radiotherapy requires a method that can simultaneously evaluate the effectiveness of cancer cells and the damage to surrounding normal cells in the irradiation field. To solve this problem, we have developed a three-dimensional oral cancer model consisting of a bilayer structure of normal human cells and cancer cells, which mimics the physiological environment of the human body. We report here on our evaluation of the safety and efficacy of radiation therapy using this three-dimensional oral cancer model, including X-rays, heavy particle beams, and neutron beams. In the future, we hope to provide multidisciplinary treatment combining BNCT with chemotherapy and other radiation therapy, depending on the type of cancer, the degree of progression, and the stage, using three-dimensional cancer models using patient- derived cells.
👀✨ Don’t miss out! May 9th, 11 UTC
📲 Join us on Zoom:
Meeting ID: 693 500 7802
Code: 920711
BY ستاره ایران 🇮🇷
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