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Prospect of exosomal circular RNAs in breast Cancer: presents and future
New paper by CIP Members
🔹Implementing precision oncology for breast cancer (BC) is a critical method for improving patient outcomes, which relies on the use of reliable biomarkers.
🔹Exosomes represent a potential alternative for the diagnosis and therapy of BC, As a “liquid biopsy” and a novel source for biomarkers.
🔹Circular RNAs (circRNAs) were recently revealed as a looping subclass of competing endogenous noncoding RNAs (ceRNAs) capable of microRNA sponging to regulate gene expression.
🔹CircRNAs are abundant in exosomes, according to various studies, and exosomal circRNAs (exo-circRNAs) play a significant role in cancer biology.
🔹Exo-circRNAs can be picked up by nearby or distant cells, affecting many features of the target cells’ pathophysiological states, thus boosting cell communication and tumor spread.
For more: https://link.springer.com/article/10.1007/s11033-022-07472-4
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