The recording of the first meeting of the Bioinformatics Discussion Club is now available online! Mark your calendars for the next meeting, which will take place on June 8 at 18:00 CET. Don't miss out and be sure to register if you haven't done so already: https://bioinf.institute/bioinfoclub

The Bioinformatics Discussion Club's second meeting is this Thursday, June 8 at 18:00 CET. Join us as we discuss "Pipeline development: Nextflow, Snakemake, or bash?".

If you haven't registered yet, please follow the instructions on https://bioinf.institute/bioinfoclub.

We can't wait to see you there!

Last chance to register for the Bioinformatics Hackathon until June 15: http://bioinf.institute/hack.

Today, June 22 at 18:00 CET, is our third Bioinformatics Club online meeting dedicated to the discussion of virtual environments and their usage in bioinformatics.

Details: https://bioinf.institute/bioinfoclub

The recording of the second meeting about pipeline development is available on YouTube. Check it out and subscribe 🩵

The recording of the third meeting is online! We discussed the pros and cons of using conda and alternative solutions to deal with virtual environments.

We are pleased to share the recording of the yesterday's meeting of IBRE Bioinformatics Club! Besides the discussion of the basic features of R Markdown and Jupyter notebooks, our experts shared their experience with various tools and platforms for reproducible research in R/Python, such as quarto.

Bioinformatics Hackathon 2023 results presentations are already live: https://www.youtube.com/live/E-VtzpypL6M

If you missed the IBRE July meeting on Cloud Computing, don't forget to check out the recording. During the meeting, we discussed the use of cloud-based computing resources and web data analysis platforms, exploring their advantages, disadvantages, and their impact on research reproducibility.

While we prepare the second season of the Bioinformatics Discussion Club (we'll keep you posted!), you can review our last meeting from the first session. We discussed the use of containers for both routine data analysis and the development of reproducible and scalable bioinformatics pipelines.

The IBRE Bioinformatics Club is a public meeting of the bioinformatics community dedicated to discussing important topics in bioinformatics, computational biology, data science, and more.

To register for future sessions

We are excited to announce the return of the IBRE Bioinformatics Club meetings in April 2024! The spring session, kicking off on April 8 at 18:00 CET, will be dedicated to discussing best practices for the analysis of genetic variation in single samples and populations, with a particular focus on human genomics.

The range of topics that will be discussed includes germline and somatic variant calling, genome-wide association studies, structural variant analysis, and the analysis of ancient DNA data. The session will feature a broad range of expert speakers from these fields. A preliminary program of the session can be found on our website: bioinf.institute/bioinfoclub

Similarly to the previous meetings, the discussion will be held in an open panel format, and we will greatly appreciate your participation in the discussion!

Registration (for new participants): bioinf.institute/bioinfoclub
Recordings will be available on youtube.com/@bioinfinstitute

Looking forward to seeing you in the Bioinformatics Club!

Check out the recording of our first IBRE Bioinformatics Club meeting in Spring 2024. The seminar was focused on discussing the best practices for short variant calling in a clinical genetics setting: https://youtu.be/Oq03SZ_Z6zs?feature=shared

The next meeting will take place on May 6.

Don’t miss the second meeting of the discussion club’s spring session that will take place today, May 6, at 18:00 CET (in 15 minutes!). We will be talking about the analysis of germline copy number variants and other types of structural variants.

https://bioinf.institute/bioinfoclub

If you missed the last seminar on May 6, you can watch the recording on our YouTube channel. The meeting was dedicated to the calling and subsequent interpretation of complex genetic variants, including copy number variants and other types of chromosomal rearrangements. Enjoy!

Following recent changes in the program of the IBRE Bioinformatics Club, we announce the final schedule for the Spring-Summer 2024 Session:

🧬 May 20, 18:00 CET – Somatic variant calling in tumor-normal and tumor-only settings.
🧬 June 10, 18:00 CET – Genotype imputation and genome-wide association studies.
🧬 June 24, 18:00 CET – Variant analysis in ancient DNA samples.
🧬 July 8, 18:00 CET – A bonus meeting dedicated to the problem of undiagnosed cases of rare diseases.

The meetings will feature expert speakers from various countries, including Greece, the UK, and the US. We look forward to seeing you! As usual, we will send you the link to the Zoom conference closer to the meeting date.

If you haven't registered yet, please visit our website.

We'd like to remind you that the third meeting of the session about genetic variation analysis will take place today, May 20, at 18:00 CET. Today's meeting will be dedicated to the discussion of somatic variant calling. The video recording will also be available later on our YouTube channel.

See you there!

We are presenting the results of our recent research into genotype-to-phenotype relationships at the European Society of Human Genetics (ESHG) 2024 meeting! If you are a participant of the conference, you can view our ePoster at the virtual platform, no. EP14.04.

Text summaries of Spring IBRE Bioinformatics Club sessions are published:
bioinf.institute/bioinfoclub/#rec715571219

We are delighted to share with you short digests and updated playlist of the latest IBRE Bioinformatics Club meetings on genome variation! The summaries are available as a part of an updated seminars webpage. Each contains references to papers, tools, and resources mentioned during the discussion. Besides, you can watch all of the Bioinformatics Club recordings through the webpage using a new embedded player.

Stay tuned, topics for the new season of the Club meeting will be announced soon!

Our research team has published a new preprint at bioRxiv!
biorxiv.org/content/10.1101/2024.10.28.620594v1

This study, "Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits", is the first part of our two-year project examining genotype-to-phenotype relationships in humans and mice. This part of the project was dedicated to systematic analysis of pleiotropy - a phenomenon of multiple phenotypic effects of individual genetic alterations.
Using our 2020 study of pleiotropy in the UK Biobank as a starting point we extended the analysis beyond complex traits, and demonstrated the universal features of pleiotropic genes. Besides, we discovered unique patterns of natural selection on pleiotropic genetic variation, with a combination of both negative and positive selection signals within pleiotropic genes.

Stay tuned for more IBRE updates! You can also find out more about IBRE research group at the website: https://bioinf.institute/research